課程資訊
課程名稱
專題研究
Seminar 
開課學期
100-1 
授課對象
醫學工程學研究所  
授課教師
謝銘鈞 
課號
Biomed7002 
課程識別碼
548 M0040 
班次
10 
學分
全/半年
半年 
必/選修
選修 
上課時間
 
上課地點
 
備註
本課程中文授課,使用英文教科書。
總人數上限:20人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1001Biomed7002_10 
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課程概述

專題研究 

課程目標
無 
課程要求
1.每星期挑選一主題報告與同學進行討論。
2.同學分享每星期實驗進度,並由老師給予改善建議。 
預期每週課後學習時數
 
Office Hours
每週二 17:30~20:00 
指定閱讀
無 
參考書目
無 
評量方式
(僅供參考)
 
No.
項目
百分比
說明
1. 
上課加出席 
100% 
 
 
課程進度
週次
日期
單元主題
第2週
09/20  1.LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett’s Esophagus? 2.Oncogenic Kras Promotes Chemotherapy-Induced Growth Factor Shedding via ADAM17 
第3週
09/27  1.Intraperitoneal photodynamic therapy mediated by a fullerene in a mouse model of abdominal dissemination of colon adenocarcinoma 2.Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type 
第4週
10/04  1.Polyethylenimine Based Magnetic Iron-Oxide Vector: The Effect of Vector Component Assembly on Cellular Entry Mechanism, Intracellular Localization, and Cellular Viability 2.Application of data mining techniques in pharmacovigilance 
第5週
10/11  1.A novel microsphere with a three-layer structure for duodenum-specific drug delivery 2.Exchange-coupled magnetic nanoparticles for efficient heat induction 
第6週
10/18  1.A novel peptide specifically targeting the vasculature of orthotopic colorectal cancer for imaging detection and drug delivery 2.A novel indirubin derivative PHII-7 potentiates adriamycin cytotoxicity via inhibiting P-glycoprotein expression in human breast cancer MCF-7/ADR cells 
第7週
10/25  1.Synergistic Enhancement of Carboplatin Efficacy with Photodynamic Therapy in a Three-Dimensional Model for Micrometastatic Ovarian Cancer 2.Identification of a peptide that interacts with Nestin protein expressed in brain cancer stem cells 
第8週
11/01  1.Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells 2.Cancer Stem Cells in Squamous Cell Carcinoma Switch between Two Distinct Phenotypes That Are Preferentially Migratory or Proliferative 
第9週
11/08  期中考週(暫停) 
第10週
11/15  1.Apoptotic cell imaging using phosphatidylserine-specific receptor-conjugated Ru(bpy)(3) (2 )-doped silica nanoparticles 2.Magnetic carbon nanotubes with particle-free surfaces and high drug loading capacity 
第11週
11/22  1.Continuous or fractionated photodynamic therapy Comparison of three PDT schemes for ovarian peritoneal micrometastasis treatment in a rat model 2.Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab 
第12週
11/29  1.Activatable aptamer probe for contrast-enhanced in vivo cancer imaging based on cell membrane protein-triggered conformation alteration 2.Noncovalent functionalization of carbon nanovectors with an antibody enables targeted drug delivery 
第13週
12/06  1.Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma 2.Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces 
第14週
12/13  1.Annexin A5 - Conjugated polymeric micelles for dual SPECT and optical detection of apoptosis 2.Nanochannel electroporation delivers precise amounts of biomolecules into living cells 
第15週
12/20  1.Optical Imaging of Mammary and Prostate Tumors in Living Animals using a Synthetic Near Infrared Zinc(II)-Dipicolylamine Probe for Anionic Cell Surfaces 
第16週
12/27  1.Direct reprogramming of stem cell properties in colon cancer cells by CD44 2.Doxorubicin-loaded human serum albumin nanoparticles surface-modified tumor types 
第17週
2012/01/03  1.Smart Multifunctional Nanostructure for Targeted Cancer Chemotherapy and Magnetic Resonance Imaging 2.The behavior after intravenous injection in mice of multiwalled carbon nanotube Fe3O4 hybrid MRI contrast agents 
第18週
2012/01/10  期末考週(暫停)